Familiarity to a Feed Additive Modulates Its Effects on Brain Responses in Reward and Memory Regions in the Pig Model
Identifieur interne : 000221 ( Main/Exploration ); précédent : 000220; suivant : 000222Familiarity to a Feed Additive Modulates Its Effects on Brain Responses in Reward and Memory Regions in the Pig Model
Auteurs : David Val-Laillet ; Paul Meurice ; Caroline ClouardSource :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Brain responses to feed flavors with or without a feed additive (FA) were investigated in piglets familiarized or not with this FA. Sixteen piglets were allocated to 2 dietary treatments from weaning until d 37: the naive group (NAI) received a standard control feed and the familiarized group (FAM) received the same feed added with a FA mainly made of orange extracts. Animals were subjected to a feed transition at d 16 post-weaning, and to 2-choice feeding tests at d 16 and d 23. Production traits of the piglets were assessed up to d 28 post-weaning. From d 26 onwards, animals underwent 2 brain imaging sessions (positron emission tomography of 18FDG) under anesthesia to investigate the brain activity triggered by the exposure to the flavors of the feed with (FA) or without (C) the FA. Images were analyzed with SPM8 and a region of interest (ROI)-based small volume correction (p < 0.05,
Url:
DOI: 10.1371/journal.pone.0162660
PubMed: 27610625
PubMed Central: 5017780
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Familiarity to a Feed Additive Modulates Its Effects on Brain Responses in Reward and Memory Regions in the Pig Model</title><author><name sortKey="Val Laillet, David" sort="Val Laillet, David" uniqKey="Val Laillet D" first="David" last="Val-Laillet">David Val-Laillet</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Meurice, Paul" sort="Meurice, Paul" uniqKey="Meurice P" first="Paul" last="Meurice">Paul Meurice</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Clouard, Caroline" sort="Clouard, Caroline" uniqKey="Clouard C" first="Caroline" last="Clouard">Caroline Clouard</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27610625</idno><idno type="pmc">5017780</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017780</idno><idno type="RBID">PMC:5017780</idno><idno type="doi">10.1371/journal.pone.0162660</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001096</idno><idno type="wicri:Area/Pmc/Curation">001095</idno><idno type="wicri:Area/Pmc/Checkpoint">000181</idno><idno type="wicri:Area/Ncbi/Merge">002165</idno><idno type="wicri:Area/Ncbi/Curation">002165</idno><idno type="wicri:Area/Ncbi/Checkpoint">002165</idno><idno type="wicri:Area/Main/Merge">000221</idno><idno type="wicri:Area/Main/Curation">000221</idno><idno type="wicri:Area/Main/Exploration">000221</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Familiarity to a Feed Additive Modulates Its Effects on Brain Responses in Reward and Memory Regions in the Pig Model</title><author><name sortKey="Val Laillet, David" sort="Val Laillet, David" uniqKey="Val Laillet D" first="David" last="Val-Laillet">David Val-Laillet</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Meurice, Paul" sort="Meurice, Paul" uniqKey="Meurice P" first="Paul" last="Meurice">Paul Meurice</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Clouard, Caroline" sort="Clouard, Caroline" uniqKey="Clouard C" first="Caroline" last="Clouard">Caroline Clouard</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Brain responses to feed flavors with or without a feed additive (FA) were investigated in piglets familiarized or not with this FA. Sixteen piglets were allocated to 2 dietary treatments from weaning until d 37: the naive group (NAI) received a standard control feed and the familiarized group (FAM) received the same feed added with a FA mainly made of orange extracts. Animals were subjected to a feed transition at d 16 post-weaning, and to 2-choice feeding tests at d 16 and d 23. Production traits of the piglets were assessed up to d 28 post-weaning. From d 26 onwards, animals underwent 2 brain imaging sessions (positron emission tomography of <sup>18</sup>FDG) under anesthesia to investigate the brain activity triggered by the exposure to the flavors of the feed with (FA) or without (C) the FA. Images were analyzed with SPM8 and a region of interest (ROI)-based small volume correction (p < 0.05, <italic>k</italic> ≥ 25 voxels per cluster). The brain ROI were selected upon their role in sensory evaluation, cognition and reward, and included the prefrontal cortex, insular cortex, fusiform gyrus, limbic system and corpus striatum. The FAM animals showed a moderate preference for the novel post-transition FA feed compared to the C feed on d 16, <italic>i</italic>.<italic>e</italic>., day of the feed transition (67% of total feed intake). The presence or absence of the FA in the diet from weaning had no impact on body weight, average daily gain, and feed efficiency of the animals over the whole experimental period (p ≥ 0.10). Familiar feed flavors activated the prefrontal cortex. The amygdala, insular cortex, and prepyriform area were only activated in familiarized animals exposed to the FA feed flavor. The perception of FA feed flavor in the familiarized animals activated the dorsal striatum differently than the perception of the C feed flavor in naive animals. Our data demonstrated that the perception of FA in familiarized individuals induced different brain responses in regions involved in reward anticipation and/or perception processes than the familiar control feed flavor in naive animals. 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Sutton</name></author><author><name sortKey="Dilger, Rn" uniqKey="Dilger R">RN Dilger</name></author><author><name sortKey="Johnson, Rw" uniqKey="Johnson R">RW Johnson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Clouard, Caroline" sort="Clouard, Caroline" uniqKey="Clouard C" first="Caroline" last="Clouard">Caroline Clouard</name><name sortKey="Meurice, Paul" sort="Meurice, Paul" uniqKey="Meurice P" first="Paul" last="Meurice">Paul Meurice</name><name sortKey="Val Laillet, David" sort="Val Laillet, David" uniqKey="Val Laillet D" first="David" last="Val-Laillet">David Val-Laillet</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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